peripheral t-cell lymphoma with cyclin d1 overexpression a case report外周t细胞淋巴瘤与细胞周期蛋白d1超表达一个案例报告.pdf

Aquino et al. Diagnostic Pathology 2012, 7:79 /content/7/1/79 CASE REPORT Open Access Peripheral T-cell Lymphoma with Cyclin D1 overexpression: a case report 1 1* 2,3 1 1 Gabriella Aquino , Renato Franco , Fioravante Ronconi , Annamaria Anniciello , Luigi Russo , Annarosaria De Chiara1 and Luigi Panico4 Abstract Peripheral T-cell lymphomas not otherwise specified are generally considered aggressive non-Hodgkin lymphomas, because of poor natural outcome and response to therapy. They show a complex karyotype without any specific genetic hallmark. We report a case of peripheral T-cell lymphoma not otherwise specified with heterogeneous nuclear Cyclin D1 immunohistochemical overexpression, due to gene copy gain, a phenomenon similar to that observed in Mantle Cell Lymphoma characterized by t(11;14)(q13;q32). In this case report we underline the diagnostic pitfall rapresented by Cyclin D1 immunoistochemical overexpression in a T-cell lymphoma. Several pitfalls could lead to misinterpretation of diagnosis, therefore, we underlined the need to integrate the classical histology and immunohistochemistry with molecular tests as clonality or Fluorescence in situ hybridization. Virtual slide: The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/ 1117747619703769 Keywords: CCND1 copy gain, Cyclin D1 over-expression, Peripheral T-cell lymphoma, FISH Background T-cell lymphomas are characterized by disease-defining Peripheral T-cell lymphomas (PTCLs) represent an het- genetic abnormalities, such as the t(2;5)(p23;q35) in ana- erogeneous group of non-Hodgkins lymphomas (NHL),