pharmacological disruption of insulin-like growth factor 1 binding to igf-binding proteins restores anabolic responses in human osteoarthritic chondrocytes药理胰岛素样生长因子1的中断绑定到igf-binding恢复人类骨关节炎软骨细胞合成代谢反应的蛋白质.pdfVIP

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pharmacological disruption of insulin-like growth factor 1 binding to igf-binding proteins restores anabolic responses in human osteoarthritic chondrocytes药理胰岛素样生长因子1的中断绑定到igf-binding恢复人类骨关节炎软骨细胞合成代谢反应的蛋白质.pdf

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pharmacological disruption of insulin-like growth factor 1 binding to igf-binding proteins restores anabolic responses in human osteoarthritic chondrocytes药理胰岛素样生长因子1的中断绑定到igf-binding恢复人类骨关节炎软骨细胞合成代谢反应的蛋白质

Available online /content/6/5/R393 Vol 6 No 5 Open Access Research article Pharmacological disruption of insulin-like growth factor 1 binding to IGF-binding proteins restores anabolic responses in human osteoarthritic chondrocytes 1 1 1 2 Frédéric De Ceuninck , Audrey Caliez , Laurent Dassencourt , Philippe Anract and Pierre Renard3 1Service de Rhumatologie, Institut de Recherches Servier, Suresnes, France 2Orthopédie B, Hôpital Cochin, Paris, France 3Service de Prospective et valorisation scientifique, Institut de Recherches Servier, Suresnes, France Corresponding author: Frédéric De Ceuninck, frederic.deceuninck@ Received: 22 Mar 2004 Revisions requested: 28 Apr 2004 Revisions received: 5 May 2004 Accepted: 19 May 2004 Published: 28 Jun 2004 Arthritis Res Ther 2004, 6:R393-R403 (DOI 10.1186/ar1201) /content/6/5/R393 © 2004 De Ceuninck et al.; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are per- mitted in all media for any purpose, provided this notice is preserved along with the articles original URL. Abstract Insulin-like growth factor 1 (IGF-1) has poor anabolic efficacy in IGF-1 from cartilage IGFBPs. We found that IGFBP-3 was the cartilage in osteoarthritis (OA), partly because of its major IGFBP secreted by OA cartilage explants and cultured sequestration by abnormally high levels of extracellular IGF- chondrocytes. NBI-31772 inhibited the binding of 125I-labeled binding proteins (IG