pathological outcomes in kidney and brain in male fischer rats given dietary ochratoxin a, commencing at one year of age病理结果在肾脏和大脑菲舍尔在雄性大鼠饮食赭曲霉毒素a,在一年的年龄开始.pdfVIP

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pathological outcomes in kidney and brain in male fischer rats given dietary ochratoxin a, commencing at one year of age病理结果在肾脏和大脑菲舍尔在雄性大鼠饮食赭曲霉毒素a,在一年的年龄开始.pdf

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pathological outcomes in kidney and brain in male fischer rats given dietary ochratoxin a, commencing at one year of age病理结果在肾脏和大脑菲舍尔在雄性大鼠饮食赭曲霉毒素a,在一年的年龄开始

Toxins 2010, 2, 1100-1110; doi:10.3390/toxins2051100 OPEN ACCESS toxins ISSN 2072-6651 /journal/toxins Article Pathological Outcomes in Kidney and Brain in Male Fischer Rats Given Dietary Ochratoxin A, Commencing at One Year of Age Peter G. Mantle 1,* and Christopher C. Nolan 2 1 Centre for Environmental Policy, Imperial College London, London, SW7 2AZ, UK 2 MRC Applied Neuroscience Group, School of Biomedical Sciences, Queens Medical Centre, Nottingham, NG7 2UH, UK; E-Mail: c.c.nolan@ * Author to whom correspondence should be addressed; E-Mail: p.mantle@imperial.ac.uk; Tel.: +44-207-5945245. Received: 9 April 2010; in revised form: 27 April 2010 / Accepted: 11 May 2010 / Published: 13 May 2010 Abstract: Malignant renal carcinoma, manifest in morbid ageing rats, is the striking component of an otherwise silent response after about nine months of exposure to ochratoxin A in the first year of life (daily intake ~100–250 µg/kg body weight). Reasons for the long latency are unclear, as is whether there would be a similar carcinogenic response if toxin exposure started at one year of age. Therefore, 24 male Fischer rats were given 100 µg ochratoxin A as a daily dietary contaminant for 35 weeks from age 50 weeks. Plasma ochratoxin A concentration reached a maximum value of ~8 µg/mL within one month of starting the toxin regimen. No renal carcinomas occurred. Four renal adenomas, two of which were only microscopic, wer