pharmacological effects of rutaecarpine as a cardiovascular protective agent药理作用的rutaecarpine心血管保护剂.pdfVIP
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pharmacological effects of rutaecarpine as a cardiovascular protective agent药理作用的rutaecarpine心血管保护剂
Molecules 2010, 15, 1873-1881; doi:10.3390/molecule
OPEN ACCESS
molecules
ISSN 1420-3049
/journal/molecules
Review
Pharmacological Effects of Rutaecarpine as a Cardiovascular
Protective Agent
1 2,
Sujie Jia and Changping Hu *
1 Department of Pharmaceutics, The Third XiangYa Hospital of Central South University, Changsha
410013, China; E-Mail: sujiejia@
2 Department of Pharmacology, School of Pharmaceutical Sciences, Central South University,
Changsha 410078, China
* Author to whom correspondence should be addressed; E-Mail: huchangping@;
Tel.: +086-731 Fax: +086-731
Received: 3 February 2010; in revised form: 1 March 2010 / Accepted: 8 March 2010 /
Published: 15 March 2010
Abstract: Many studies indicate that traditional Chinese herbs are beneficial in the
prevention and treatment of cardiovascular diseases. Evodia rutaecarpa (‘Wu-Chu-Yu’)
remains the most popular and multi-purpose herb traditionally used in China for treatment
of headache, abdominal pain, postpartum hemorrhage, dysentery and amenorrhea.
Rutaecarpine is one of the intriguing indolopyridoquinazoline alkaloids isolated from
‘Wu-Chu-Yu’. Rutaecarpine has been shown to have cardiovascular biological effects such
as inotropic and chronotropic, vasorelaxant, anti-platelet aggregation and
anti-inflammatory effects. Furthermore, it has been reported that rutaecarpine h
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