pharmacology of ginsenosides a literature review人参皂苷的药理学文献综述.pdfVIP

Leung and Wong Chinese Medicine 2010, 5:20 /content/5/1/20 R E V I E W Open Access Review Pharmacology of ginsenosides: a literature review 1 2 Kar Wah Leung* and Alice Sze-Tsai Wong Abstract The therapeutic potential of ginseng has been studied extensively, and ginsenosides, the active components of ginseng, are shown to be involved in modulating multiple physiological activities. This article will review the structure, systemic transformation and bioavailability of ginsenosides before illustration on how these molecules exert their functions via interactions with steroidal receptors. The multiple biological actions make ginsenosides as important resources for developing new modalities. Yet, low bioavailability of ginsenoside is one of the major hurdles needs to be overcome to advance its use in clinical settings. Review Rx, where the R stands for the root and the x describes Background the chromatographic polarity in an alphabetical order [7], Panax ginseng (Renshen, Chinese ginseng) is commonly for example, Ra is the least polar compound and Rb is used either by itself or in combination with other medici- more polar than Ra. Over 30 ginsenosides have been nal ingredients as a key herb in Chinese medicine. A identified and classified into two categories: (1) the 20(S)- member of the Araliaceae family, the genus name Panax protopanaxadiol (PPD) (Rb1, Rb2, Rb3, Rc, Rd, Rg3, Rh2, was derived from the Greek word meaning all-healing Rs1) and (2) the 20(S)-protopanaxatr