physiological studies on the sex-linked dwarfism of the fowl a review on the search for the genes primary effect家禽的生理研究的与性别有关的侏儒症回顾寻找基因的主要效果.pdf

Review article Physiological studies on the sex-linked dwarfism of the fowl: a review on the search for the gene’s primary effect M. Tixier-Boichard L.M. Huybrechts E. Kühn2E. Decuypere3 J. Charrier P. Mongin 1 Institut National de la Recherche Agronomique, Laboratoire de Génétique Factorielle, 78350 Jouy-en-Josas, France; 2 Zoological Institute, Laboratory of Comparative Endocrinology, Naamsestraat 61, 3000 Leuven, Belgium; 3 Laboratory for Physiology of Domestic Animais, Kardinaal Mercierlaan 92, 3030 Heverlee, Belgium; 4 Institut National de la Recherche Agronomique, Station de Physiologie de la Croissance, 9place Vala, 34060Montpellier, France; 5 Institut National de la Recherche Agronomique, Station de Recherches Avicoles, Centre de Recherches de Nouzilly, 37380 Monnaie, France (received31 May 1988, accepted 26 September 1988) Summary mdash; The results obtained in the last 10 yars on the endocrinological and metabolic effects of the sex-linked dwarf gene of the fowl are reviewed in order to identify its mode of action on growth and other traits. Among the main factors involved in growth regulation, thyroid hormones, T4 and T3, growth hor- mone, GH, and its related growth factor, IGF-I, were the most studied in dwarfs. These birds are characterized by low circulating levels of T3 and IGF-I in spite of normal or even increased levels of T4 and GH. The T3 deficiency is explained by a lower peripheral activity of T4 monodeiodination which could be related to an abnormal T4 uptake by the cell, particularly the hepatocyte. The low production of IGF-I could be related to a deficient GH receptor, as suggested by the decreased GH binding observed in the liver of dwarf birds. Both T3 and IGF-I synthesis may share common path- ways since thyroidectomy also decreases IGF-I level while a GH injection stimulates the T4 t