phytomedicine in otorhinolaryngology and pulmonology clinical trials with herbal remedies植物学期刊与草药耳鼻喉科学和肺学临床试验.pdfVIP

Pharmaceuticals 2012, 5, 853-874; doi:10.3390/ph5080853 OPEN ACCESS Pharmaceuticals ISSN 1424-8247 /journal/pharmaceuticals Review Phytomedicine in Otorhinolaryngology and Pulmonology: Clinical Trials with Herbal Remedies Koosha Ghazi-Moghadam 1,2, Hasan Mete Inançlı 3, Nazanin Bazazy 1, Peter K. Plinkert 1, Thomas Efferth 4 and Serkan Sertel 1,2,4,* 1 Department of Otorhinolaryngology, Head Neck Surgery, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany 2 Molecular Mechanisms of Head and Neck T—A102, Division Signal Transduction and Growth Control, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany 3 Department of Otorhinolaryngology, Near East University Hospital, 922022 Lefkosa, Turkish Republic of Northern Cyprus 4 Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Staudingerweg 5, 55099 Mainz, Germany * Author to whom correspondence should be addressed; E-Mail: serkan.sertel@med.uni-heidelberg.de; Tel.: +49-6221-56-39502; Fax: +49-6221-56-4641. Received: 5 July 2012 / Accepted: 8 August 2012 / Published: 20 August 2012 Abstract: Phytomedicine has become an important alternative treatment option for patients in the Western world, as they seek to be treated in a holistic and natural way after an unsatisfactory response to conventional drugs. Ever since herbal remedies have been introduced in the Western world, clinicians have raised concerns over their efficacy and