pi3k and pkc contribute to membrane depolarization mediated by α2-adrenoceptors in the canine isolated mesenteric veinpi3k和pkc导致膜去极化α2-adrenoceptors介导的犬类分离肠系膜静脉.pdfVIP

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pi3k and pkc contribute to membrane depolarization mediated by α2-adrenoceptors in the canine isolated mesenteric veinpi3k和pkc导致膜去极化α2-adrenoceptors介导的犬类分离肠系膜静脉.pdf

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pi3k and pkc contribute to membrane depolarization mediated by α2-adrenoceptors in the canine isolated mesenteric veinpi3k和pkc导致膜去极化α2-adrenoceptors介导的犬类分离肠系膜静脉

BMC Physiology BioMed Central Research article Open Access PI3K and PKC contribute to membrane depolarization mediated by α2-adrenoceptors in the canine isolated mesenteric vein Ilia A Yamboliev*†1 and Violeta N Mutafova-Yambolieva†2 Address: 1Department of Pharmacology and Center of Biomedical Research Excellence, University of Nevada School of Medicine, Reno, Nevada 89557, USA and 2Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada 89557, USA Email: Ilia A Yamboliev* - yambo@; Violeta N Mutafova-Yambolieva - vnm@ * Corresponding author †Equal contributors Published: 15 June 2005 Received: 09 October 2004 Accepted: 15 June 2005 BMC Physiology 2005, 5:9 doi:10.1186/1472-6793-5-9 This article is available from: /1472-6793/5/9 © 2005 Yamboliev and Mutafova-Yambolieva; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Norepinephrine (NE), a classic neurotransmitter in the sympathetic nervous system, induces vasoconstriction of canine isolated mesenteric vein that is accompanied by a sustained membrane depolarization. The mechanisms underlying the NE-elicited membrane depolarization remain undefined. In the present study we hypothesized that phosphatidylinositol 3-kinase (PI3K) and protein kinase C (PKC) are involved in the electri