pigmented paraganglioma of the kidney a case report色素副神经节瘤的肾脏病例报告.pdfVIP

Zhao et al. Diagnostic Pathology 2012, 7:77 /content/7/1/77 CASE REPORT Open Access Pigmented paraganglioma of the kidney: a case report * Ling Zhao, Jie Luo, Honglei Zhang and Jiping Da Abstract Paragangliomas are rare neoplasms arising from undifferentiated cells of the primitive neural crest. We report a case of a 57-year-old patient with renal pigmented paraganglioma that was an incidental finding. Histopathological examination showed typical morphology of paraganglioma, as well as the unusual feature of large amounts of pigment in the cytoplasm of the tumor cells which was confirmed by bleached Fontana-Masson. Electron microscopy showed abundant, pleomorphic electron-dense granules consistent with neuromelanin. The tumor cells were positive for CD56 and chromogranin A, negative for HMB-45. The unique morphologic appearance represents divergent differentiation from neural crest. To our knowledge, the present case represents the first example of pigmented paraganglioma of the kidney. Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/ vs/2017147293711495. Keywords: Pigmented paraganglioma, Kidney, Differential diagnosis Background involving the left kidney (Figure 1). There were no signs of Extra-adrenal paraganglia are specialized neural crest- excess catecholamine secretion, and the blood pressure derived cells that are scattered from the base of the skull was 123/84 mmHg. Routine laboratory examinations were down to the pelvic floor. Paragangliomas are tumors that within normal limits, including the serum tumor markers. arise from chromaffin cells at a variety of anatomic site