perturbations of lipid metabolism indexed by lipidomic biomarkers脂质代谢的扰动被lipidomic生物标志物.pdfVIP

Metabolites 2012, 2, 1-18; doi:10.3390/metabo2010001 OPEN ACCESS metabolites ISSN 2218-1989 /journal/metabolites/ Review Perturbations of Lipid Metabolism Indexed by Lipidomic Biomarkers Antonin Lamaziere 1, Claude Wolf 1,3,* and Peter J. Quinn 2 1 INSERM U1057, Faculte de Medicine, “P. et M. Curie” 27 rue Chaligny, Paris 75012, France; E-Mail: antonin.lamaziere@upmc.fr 2 Department of Biochemistry, King’s College London, 150 Stamford Street, London SE1 9NH, UK; E-Mail: p.quinn@kcl.ac.uk 3 Laboratory of Mass Spectrometry, Applied Lipid Investigation (APLIPID®), Paris 75012, France * Author to whom correspondence should be addressed; E-Mail: claude.wolf@upmc.fr; Tel. +33-6-95-52-29; Fax: +33-1-40-01-13-47. Received: 28 November 2011; in revised form: 21 December 2011 / Accepted: 22 December 2011/ Published: 4 January 2012 Abstract: The lipidome of the liver and the secreted circulating lipoproteins can now be interrogated conveniently by automated mass spectrometric methods. Multivariate analysis of the liver and serum lipid composition in various animal modes or in human patients has pointed to specific molecular species markers. The perturbations of lipid metabolism can be categorized on the basis of three basic pathological mechanisms: (1) an accelerated rate of de novo lipogenesis; (2) perturbation of the peroxisome pathway of ether-lipid and very-long-chain fatty acid biosynthesis; (3) a change in the rate of interconversion of essential omega-3 and -6 polyunsaturated fatty