partition function and base pairing probabilities of rna heterodimers配分函数和rna形成的碱基配对概率.pdfVIP

Algorithms for Molecular Biology BioMed Central Research Open Access Partition function and base pairing probabilities of RNA heterodimers 1 1 1 Stephan H Bernhart* , Hakim Tafer , Ulrike Mückstein , Christoph Flamm2,1, Peter F Stadler2,1,3 and Ivo L Hofacker 1 1 Address: Theoretical Biochemistry Group, Institute for Theoretical Chemistry, University of Vienna, Währingerstrasse 17, Vienna, Austria, 2Bioinformatics Group, Department of Computer Science and Interdisciplinary Center for Bioinformatics, University of Leipzig, Härtelstrasse 16– 18, D-04170 Leipzig, Germany and 3The Santa Fe Institute, 1399 Hyde Park Rd., Santa Fe, New Mexico Email: Stephan H Bernhart* - berni@tbi.univie.ac.at; Hakim Tafer - htafer@tbi.univie.ac.at; Ulrike Mückstein - ulim@tbi.univie.ac.at; Christoph Flamm - xtof@tbi.univie.ac.at; Peter F Stadler - studla@tbi.univie.ac.at; Ivo L Hofacker - ivo@tbi.univie.ac.at * Corresponding author Published: 16 March 2006 Received: 16 February 2006 Accepted: 16 March 2006 Algorithms for Molecular Biology2006, 1:3 doi:10.1186/1748-7188-1-3 This article is available from: /content/1/1/3 © 2006Bernhart et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: RNA has been recognized as a key player in cellular regulation in recent years. In many cases, non-coding RNAs exert their function