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particulate air pollution and survival in a copd cohort微粒空气污染在copd组和生存.pdf

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particulate air pollution and survival in a copd cohort微粒空气污染在copd组和生存

Environmental Health BioMed Central Research Open Access Particulate air pollution and survival in a COPD cohort Antonella Zanobetti*, Marie-Abele C Bind and Joel Schwartz Address: Department of Environmental Health, Harvard School of Public Health, Boston, USA Email: Antonella Zanobetti* - azanobet@; Marie-Abele C Bind - mbind@; Joel Schwartz - jschwrtz@ * Corresponding author Published: 10 October 2008 Received: 19 June 2008 Accepted: 10 October 2008 Environmental Health 2008, 7:48 doi:10.1186/1476-069X-7-48 This article is available from: /content/7/1/48 © 2008 Zanobetti et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Several studies have shown cross-sectional associations between long term exposure to particulate air pollution and survival in general population or convenience cohorts. Less is known about susceptibility, or year to year changes in exposure. We investigated whether particles were associated with survival in a cohort of persons with COPD in 34 US cities, eliminating the usual cross-sectional exposure and treating PM 10 as a within city time varying exposure. Methods: Using hospital discharge data, we con