polarized subsets of human t-helper cells induce distinct patterns of chemokine production by normal and systemic sclerosis dermal fibroblasts极化的子集人类辅助细胞诱导不同的趋化因子的生产模式由正常和系统性硬化症真皮成纤维细胞.pdfVIP
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polarized subsets of human t-helper cells induce distinct patterns of chemokine production by normal and systemic sclerosis dermal fibroblasts极化的子集人类辅助细胞诱导不同的趋化因子的生产模式由正常和系统性硬化症真皮成纤维细胞
Available online /content/8/1/R10
Vol 8 No 1 Open Access
Research article
Polarized subsets of human T-helper cells induce distinct patterns
of chemokine production by normal and systemic sclerosis dermal
fibroblasts
1 1 2 1
Carlo Chizzolini , Yann Parel , Agneta Scheja and Jean-Michel Dayer
1Immunology and Allergy, Geneva University Hospital, Geneva School of Medicine, Rue Micheli-du-Crest, 24, 1211 Geneva 14, Switzerland
2Division of Rheumatology, Lund University Hospital, 221 85 Lund, Sweden
Corresponding author: Carlo Chizzolini, chizzolini@medecine.unige.ch
Received: 25 Jun 2005 Revisions requested: 14 Jul 2005 Revisions received: 10 Oct 2005 Accepted: 3 Nov 2005 Published: 30 Nov 2005
Arthritis Research Therapy 2006, 8:R10 (doi:10.1186/ar1860)
This article is online at: /content/8/1/R10
© 2005 Chizzolini et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
The role of fibroblasts in inflammatory processes and their semipermeable membrane from living T cells activated by CD3
cross-talk with T cells is increasingly being recognized. Our aim cross-linking. We observed further differences when we
was to explore the capacity of dermal fibroblasts to produce explored signal transduction pathway usage in fibroblasts.
inflammatory chemokines potentially involved in fibrosi
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