polymorphism in the tumour necrosis factor receptor ii gene is associated with circulating levels of soluble tumour necrosis factor receptors in rheumatoid arthritis肿瘤坏死因子受体2基因的多态性与循环水平的可溶性肿瘤坏死因子受体类风湿性关节炎.pdf

Available online /content/7/6/R1227 Vol 7 No 6 Open Access Research article Polymorphism in the tumour necrosis factor receptor II gene is associated with circulating levels of soluble tumour necrosis factor receptors in rheumatoid arthritis John R Glossop, Peter T Dawes, Nicola B Nixon and Derek L Mattey Staffordshire Rheumatology Centre, University Hospital of North Staffordshire, Stoke-on-Trent, UK Corresponding author: Derek L Mattey, derek.mattey@uhns.nhs.uk Received: 17 Mar 2005 Revisions requested: 25 Apr 2005 Revisions received: 28 Jul 2005 Accepted: 10 Aug 2005 Published: 7 Sep 2005 Arthritis Research Therapy 2005, 7:R1227-R1234 (DOI 10.1186/ar1816) This article is online at: /content/7/6/R1227 © 2005 Glossop et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/ 2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Levels of soluble tumour necrosis factor receptors (sTNFRs) are phytohaemagglutinin. Serum levels of the two sTNFRs (sTNF-RI elevated in the circulation of patients with rheumatoid arthritis and sTNF-RII) were positively correlated in both populations, (RA). Although these receptors can act as natural inhibitors of and the level of each sTNFR was significantly higher in the tumour necrosis factor-α, levels of sTNFRs in RA appear to be patients with established disease (P 0.0001). Multiple insufficient to prevent tumour necrosis factor-α induced regression analyses corrected for age, sex and d