physical activity, sedentary behaviors, and estimated insulin sensitivity and secretion in pregnant and non-pregnant women体育活动、久坐行为和估计胰岛素敏感性和分泌在怀孕和怀孕妇女.pdf

Gradmark et al. BMC Pregnancy and Childbirth 2011, 11:44 /1471-2393/11/44 RESEARCH ARTICLE Open Access Physical activity, sedentary behaviors, and estimated insulin sensitivity and secretion in pregnant and non-pregnant women 1† 1,2,3† 1,3,4 1,5 6 Anna Gradmark , Jeremy Pomeroy , Frida Renström , Susanne Steiginga , Margareta Persson , 7 7 8 9 10 1,3,4* Antony Wright , Les Bluck , Magnus Domellöf , Steven E Kahn , Ingrid Mogren and Paul W Franks Abstract Background: Overweight and obesity during pregnancy raise the risk of gestational diabetes and birth complications. Lifestyle factors like physical activity may decrease these risks through beneficial effects on glucose homeostasis. Here we examined physical activity patterns and their relationships with measures of glucose homeostasis in late pregnancy compared to non-pregnant women. Methods: Normal weight and overweight women without diabetes (N = 108; aged 25-35 years) were studied; 35 were pregnant (in gestational weeks 28-32) and 73 were non-pregnant. Insulin sensitivity and b-cell response were estimated from an oral glucose tolerance test. Physical activity was measured during 10-days of free-living using a combined heart rate sensor and accelerometer. Total (TEE), resting (REE), and physical activity (PAEE) energy expenditure were measured using doubly-labeled water and expired gas indirect calorimetry. Results: Total activity was associated with reduced first-phase insulin response in both pregnant (Regression r2 = 0.11; Spearman r = -0.47; p = 0.007) and non-pregnant women (Regression r2 =