potential health-modulating effects of isoflavones and metabolites via activation of ppar and ahr潜在health-modulating异黄酮的影响和通过激活ppar和ahr的代谢物.pdfVIP

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potential health-modulating effects of isoflavones and metabolites via activation of ppar and ahr潜在health-modulating异黄酮的影响和通过激活ppar和ahr的代谢物.pdf

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potential health-modulating effects of isoflavones and metabolites via activation of ppar and ahr潜在health-modulating异黄酮的影响和通过激活ppar和ahr的代谢物

Nutrients 2010, 2, 241-279; doi:10.3390/nu2030241 OPEN ACCESS nutrients ISSN 2072-6643 /journal/nutrients Review Potential Health-modulating Effects of Isoflavones and Metabolites via Activation of PPAR and AhR Svjetlana Medjakovic 1,2,†, Monika Mueller 1,2,† and Alois Jungbauer 1,2,* 1 Department of Biotechnology, University of Natural Resources and Applied Life Sciences Vienna, Muthgasse 18, 1190 Vienna, Austria; E-Mails: svjetlana.medjakovic@boku.ac.at (S.M.); monika.mueller@boku.ac.at (M.M.) 2 Christian-Doppler-Laboratory of Receptor Biotechnology, Muthgasse 18, 1190 Vienna, Austria † These authors contributed equally to this work. * Author to whom correspondence should be addressed: E-Mail: alois.jungbauer@boku.ac.at. Received: 21 December 2009 / Accepted: 23 February 2010 / Published: 26 February 2010 Abstract: Isoflavones have multiple actions on cell functions. The most prominent one is the activation of estrogen receptors. Other functions are often overlooked, but are equally important and explain the beneficial health effects of isoflavones. Isoflavones are potent dual PPARα/γ agonists and exert anti-inflammatory activity, which may contribute to the prevention of metabolic syndrome, atherosclerosis and various other inflammatory diseases. Some isoflavones are potent aryl hydrocarbon receptor (AhR) agonists and induce cell cycle arrest, chemoprevention and modulate xenobiotic metabolism. This review discusses effects mediated by the activation of AhR and PPARs and casts a light on the concert