potential of the dietary antioxidants resveratrol and curcumin in prevention and treatment of hematologic malignancies潜在的膳食抗氧化剂白藜芦醇和姜黄素在血液恶性肿瘤的预防和治疗.pdfVIP

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potential of the dietary antioxidants resveratrol and curcumin in prevention and treatment of hematologic malignancies潜在的膳食抗氧化剂白藜芦醇和姜黄素在血液恶性肿瘤的预防和治疗.pdf

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potential of the dietary antioxidants resveratrol and curcumin in prevention and treatment of hematologic malignancies潜在的膳食抗氧化剂白藜芦醇和姜黄素在血液恶性肿瘤的预防和治疗

Molecules 2010, 15, 7035-7074; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Review Potential of the Dietary Antioxidants Resveratrol and Curcumin in Prevention and Treatment of Hematologic Malignancies Mareike Kelkel 1, Claus Jacob 2, Mario Dicato 1 and Marc Diederich 1,* 1 Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Fondation de Recherche Cancer et Sang, Hôpital Kirchberg, 9 Rue Edward Steichen, 2540 Luxembourg, Luxembourg; E-Mail: mareike.kelkel@lbmcc.lu (M.K.) 2 Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, 66123 Saarbruecken, Germany; E-Mail: c.jacob@mx.uni-saarland.de * Author to whom correspondence should be addressed; E-Mail: marc.diederich@lbmcc.lu; Tel.: +352-2468-4040; Fax: +352-2468-4060. Received: 6 September 2010; in revised form: 2 October 2010/ Accepted: 11 October 2010 / Published: 12 October 2010 Abstract: Despite considerable improvements in the tolerance and efficacy of novel chemotherapeutic agents, the mortality of hematological malignancies is still high due to therapy relapse, which is associated with bad prognosis. Dietary polyphenolic compounds are of growing interest as an alternative approach, especially in cancer treatment, as they have been proven to be safe and display strong antioxidant properties. Here, we provide evidence that both resveratrol and curcumin possess huge potential for application as both chemopreventive agents and anticancer drugs and might represent promising candidates for