poly(alkyl methacrylate) tooth coatings for dental care evaluation of the demineralisation-protection benefit using a time-resolved in vitro method聚(甲基丙烯酸烷基酯)牙齿涂层的牙科保健评估demineralisation-protection使用时间分辨体外方法中获益.pdfVIP

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poly(alkyl methacrylate) tooth coatings for dental care evaluation of the demineralisation-protection benefit using a time-resolved in vitro method聚(甲基丙烯酸烷基酯)牙齿涂层的牙科保健评估demineralisation-protection使用时间分辨体外方法中获益.pdf

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poly(alkyl methacrylate) tooth coatings for dental care evaluation of the demineralisation-protection benefit using a time-resolved in vitro method聚(甲基丙烯酸烷基酯)牙齿涂层的牙科保健评估demineralisation-protection使用时间分辨体外方法中获益

Polymers 2011, 3, 314-329; doi:10.3390/polym3010314 OPEN ACCESS polymers ISSN 2073-4360 /journal/polymers Article Poly(alkyl methacrylate) Tooth Coatings for Dental Care: Evaluation of the Demineralisation-Protection Benefit Using a Time-Resolved In Vitro Method Birthe V. Nielsen 1,2, Thomas G. Nevell 1, Eugen Barbu 1, James R. Smith 1, Gareth D. Rees 3 and John Tsibouklis 1,* 1 School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, Hampshire, PO1 2DT, UK; E-Mails: b.v.nielsen@greenwich.ac.uk (B.V.N.); tom.nevell@port.ac.uk (T.G.N.); eugen.barbu@port.ac.uk (E.B.); james.smith@port.ac.uk (J.R.S.) 2 School of Science, University of Greenwich, Chatham Maritime, Kent, ME1 4TB, UK 3 GlaxoSmithKline RD, St George‘s Avenue, Weybridge, Surrey, KT13 0DE, UK; E-Mail: gareth.d.rees@ (G.D.R.) * Author to whom correspondence should be addressed; E-Mail: john.tsibouklis@port.ac.uk . Received: 8 December 2010; in revisedform: 24 December 2010 / Accepted: 17 January 2011 / Published: 19 January 2011 Abstract: An in vitro method for the time-resolved quantification of acid-mediated tooth demineralisation has been developed and evaluated against putative non-permanent protective formulations based on a series of poly(alkyl methacrylate)s. Using a thermostatted carousel, dentally relevant substrates consisting of hydroxyapatite discs or sections of bovine teeth have been exposed to aqueous citric acid under controlled conditions, before and after being treated with the polymeric coatings. The dissoluti