polyanionic drugs and viral oncogenesis a novel approach to control infection, tumor-associated inflammation and angiogenesis阴离子药物和病毒性肿瘤形成一个新颖的方法来控制感染,肿瘤相关炎症和血管生成.pdfVIP

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polyanionic drugs and viral oncogenesis a novel approach to control infection, tumor-associated inflammation and angiogenesis阴离子药物和病毒性肿瘤形成一个新颖的方法来控制感染,肿瘤相关炎症和血管生成.pdf

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polyanionic drugs and viral oncogenesis a novel approach to control infection, tumor-associated inflammation and angiogenesis阴离子药物和病毒性肿瘤形成一个新颖的方法来控制感染,肿瘤相关炎症和血管生成

Molecules 2008, 13, 2758-2785; DOI : 10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Review Polyanionic Drugs and Viral Oncogenesis: a Novel Approach to Control Infection, Tumor-associated Inflammation and Angiogenesis Chiara Urbinati, Paola Chiodelli and Marco Rusnati * Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Italy; E-mails: urbinati@med.unibs.it (C.U.); chiodell@med.unibs.it (P.C.). * Author to whom correspondence should be addressed; E-mail: rusnati@med.unibs.it; Tel.: +39- 0303717315; Fax: +39-0303701157. Received: 4 September 2008; in revised form: 13 October 2008 / Accepted: 29 October 2008 / Published: 6 November 2008 Abstract: Polyanionic macromolecules are extremely abundant both in the extracellular environment and inside the cell, where they are readily accessible to many proteins for interactions that play a variety of biological roles. Among polyanions, heparin, heparan sulfate proteoglycans (HSPGs) and glycosphingolipids (GSLs) are widely distributed in biological fluids, at the cell membrane and inside the cell, where they are implicated in several physiological and/or pathological processes such as infectious diseases, angiogenesis and tumor growth. At a molecular level, these processes are mainly mediated by micr