predictors for pathologically confirmed aortitis after resection of the ascending aorta a 12-year danish nationwide population-based cross-sectional study预测切除后病理证实主动脉炎升主动脉的12年丹麦全国以人群为基础的横断面研究.pdfVIP

Schmidt et al. Arthritis Research Therapy 2011, 13:R87 /content/13/3/R87 RESEARCH ARTICLE Open Access Predictors for pathologically confirmed aortitis after resection of the ascending aorta: A 12-year Danish nationwide population-based cross-sectional study 1,2* 1 1 2 1 Jean Schmidt , Kaare Sunesen , Jette B Kornum , Pierre Duhaut and Reimar W Thomsen Abstract Introduction: Assessing the prevalence of, and predictors for, pathologically-confirmed inflammation of the aorta in Denmark, using a nationwide population-based study design. Methods: We identified all adults with first-time surgery on the ascending aorta between January 1, 1997 and March 1, 2009 in Denmark. Presence of aortic inflammation was ascertained through linkage to a nationwide pathology registry. We used logistic regression to compute prevalence odds ratios (ORs) for sex, age at surgery, cardiovascular risk factors, cancer, connective tissue disease, and infectious diseases associated with the presence of aortitis. Results: A total of 1,210 adults underwent resection of the ascending aorta, of who 610 (50.4%) had tissue submitted for pathological examination. Aortitis was found in 37 (6.1%) patients whose tissue was examined. Ten of the 37 patients were diagnosed with conditions known to be associated with aortitis or aortic aneurysm: five patients with temporal arteritis, one with Crohn’s disease, one with rheumatoid arthritis, one with systemic lupus erythematosus, one with infectious aortitis, and one with Marfan’s disease. Twenty-seven patients had idiopathic aortitis. Predictors of aortitis included history of connective tissue disease (adjusted OR 4.7, 95% confidence interval (CI) 1.6, 13.6), diabetes (OR 5.2,