primary pleural angiosarcoma as a mimicker of mesothelioma a case report主要胸膜间皮瘤案例报告的血管肉瘤是模仿别人的人.pdfVIP

Kao et al. Diagnostic Pathology 2011, 6:130 /content/6/1/130 CASE REPORT Open Access Primary pleural angiosarcoma as a mimicker of mesothelioma: a case report 1 2 3 1 4 1* Yu-Chien Kao , Jyh-Ming Chow , Kum-Min Wang , Chia-Lang Fang , Jan-Show Chu and Chi-Long Chen Abstract Primary pleural angiosarcoma is a rare and clinically aggressive tumor. Patients usually present with chest pain, dyspnea, hemoptysis and/or cough. Radiologic studies reveal diffuse pleural thickening and pleural effusion with or without mass lesion. The clinical and radiological features both resemble those of mesothelioma, and its definite diagnosis requires careful histologic examination. However, frequent epithelioid feature and immunoreactivity to cytokeratin in primary pleural angiosarcoma further complicate the pathologic diagnosis. The use of proper immunohistochemical stains is often needed to support endothelial differentiation in the tumor cells and to exclude metastatic carcinoma and mesothelioma. We report the case of a 49-year-old male patient with primary pleural angiosarcoma, who presented with initial hemothorax, followed by a rapid progress to an inoperable status. Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/ vs/1059343251633446 Keywords: angiosarcoma, pleura, mesothelioma, sarcoma, pathology Background We describe herein a case of PPA, to highlight its Angiosarcoma is an uncommon malignant tumor of aggressive clinical behavior and the diagnostic pitfalls. endothelial differentiation. It accounts for about 1%