primary pulmonary malignant melanoma a clinicopathologic study of two cases原发性肺恶性黑色素瘤的临床病理的研究两种情况.pdfVIP

Gong et al. Diagnostic Pathology 2012, 7:123 /content/7/1/123 CASE REPORT Open Access Primary pulmonary malignant melanoma: a clinicopathologic study of two cases 1 1 1 1 1 1 1 Li Gong , Xiao-Yan Liu , Wen-Dong Zhang , Shao-Jun Zhu , Li Yao , Xiu-Juan Han , Miao Lan , Yan-Hong Li1,2,3* and Wei Zhang1,3* Abstract: Malignant melanoma involving the respiratory tract is nearly always metastatic in origin, and primary tumors are very rare. To our knowledge, about 30 cases have been reported in the English literature, one of which involved multiple brain metastases. Here, we report two cases of primary pulmonary malignant melanoma. The first case, which occurred in a 52-year-old Chinese female patient who died 4 months after the initial diagnosis, involved rapid intrapulmonary and intracranial metastases. The second patient, a 65-year-old female, underwent surgical excision, and clinical examination, histopathological characteristics, and immunohistochemical features supported the diagnosis of pulmonary malignant melanoma. No evidence for recurrence and/or metastasis has been found more than one year after the initial surgery. To establish the diagnosis of primary pulmonary malignant melanoma, any extrapulmonary origin must be excluded by detailed examination. Moreover, the tumor should be removed surgically whether it occurs as a single lesion or multiple lesions. Virtual slide: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/ 1480477335765055. Keywords: Primary pulmonary melanoma, Surgical resection, Chemotherapy, Metastasis, Treatment Introduction Case presentation Malignant melanoma occurs mos