proanthocyanidins from grape seeds modulate the nf-κb signal transduction pathways in rats with tnbs-induced ulcerative colitis葡萄籽原花青素从调整nf-κb信号转导途径与tnbs-induced溃疡性结肠炎大鼠.pdfVIP

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proanthocyanidins from grape seeds modulate the nf-κb signal transduction pathways in rats with tnbs-induced ulcerative colitis葡萄籽原花青素从调整nf-κb信号转导途径与tnbs-induced溃疡性结肠炎大鼠.pdf

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proanthocyanidins from grape seeds modulate the nf-κb signal transduction pathways in rats with tnbs-induced ulcerative colitis葡萄籽原花青素从调整nf-κb信号转导途径与tnbs-induced溃疡性结肠炎大鼠

Molecules 2011, 16, 6721-6731; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Proanthocyanidins from Grape Seeds Modulate the NF-κB Signal Transduction Pathways in Rats with TNBS-Induced Ulcerative Colitis Xiaoli Li 1,3, Xiaolai Yang 2, Yongqing Cai 4, Hong Qin 1, Li Wang 1, Yanhong Wang 2, 1 1 1 1 1 1 1 Yanhui Huang , Xiaoxia Wang , Shuai Yan , Liping Wang , Xin Zhao ,Wan Li , Sijia Li , Jiajia Chen 1 and Yongjie Wu 1,* 1 Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Department of College of Medicine, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China 2 People’s Hospital of Gansu Province, Lanzhou 730000, China 3 Department of Pharmacology, College of Medicine, The Third Military Medical University, Chongqing 400038, China 4 Department of Pharmacy, Southwestern Hospital, The Third Military Medical University, Chongqing 400038, China * Author to whom correspondence should be addressed; E-Mail: wuyj@. Received: 5 July 2011; in revised form: 29 July 2011 / Accepted: 3 August 2011 / Published: 8 August 2011 Abstract: To elucidate the molecular mechanisms involved in the therapeutic effects of proanthocyanidins from grape seeds (GSPE), we explore whether GSPE regulates the inflammatory response of TNBS-induced colitis in rats at the levels of NF-κB signal transduction pathwa