profound differences in virus population genetics correspond to protection from cd4 decline resulting from feline lentivirus coinfection深刻的病毒种群遗传学差异对应于保护cd4下降造成猫慢病毒合并感染.pdfVIP

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profound differences in virus population genetics correspond to protection from cd4 decline resulting from feline lentivirus coinfection深刻的病毒种群遗传学差异对应于保护cd4下降造成猫慢病毒合并感染.pdf

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profound differences in virus population genetics correspond to protection from cd4 decline resulting from feline lentivirus coinfection深刻的病毒种群遗传学差异对应于保护cd4下降造成猫慢病毒合并感染

Viruses 2010, 2, 2663-2680; doi:10.3390/v2122663 OPEN ACCESS viruses ISSN 1999-4915 /journal/viruses Article Profound Differences in Virus Population Genetics Correspond to Protection from CD4 Decline Resulting from Feline Lentivirus Coinfection Abinash Padhi 1, Howard Ross 2, Julie Terwee 3, Sue VandeWoude 3 and Mary Poss 1,4,5,* 1 Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA; E-Mail: aup17@ 2 School of Biological Sciences, University of Auckland, Auckland, 1142, New Zealand; E-Mail: h.ross@auckland.ac.nz 3 Department of Microbiology, Immunology, and Pathology, Colorado State University, Ft. Collins, CO 80523, USA; E-Mails: jat@ (J.T.); Sue.Vandewoude@ (S.V.) 4 Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA 5 208 Mueller Lab, Center for Infectious Disease Dynamics, The Pennsylvania State University, University Park, PA 16802, USA * Author to whom correspondence should be addressed; E-Mail: mposs@; Tel.: +1-814-867 1213, Fax: +1-814-865 9131. Received: 9 November 2010; in revised form: 25 November 2010 / Accepted: 29 November 2010 / Published: 10 December 2010 Abstract: CD4 decline is a hallmark of disease onset in individuals infected with Feline Immunodeficiency Virus (FIV) or Human Immunodeficiency Virus type 1 (HIV-1). Cats that are infected with a poorly replicating, apathogenic FIV (PLV) prior to exposure to a virulent FIV strain (FIVC) maintain CD4 numbers by mechanisms that are not correlated with a measurable adaptive immune respons