原创力文档protocol for a randomised controlled trial investigating the effectiveness of an online e health application for the prevention of generalised anxiety disorder协议为随机对照试验对在线e健康应用程序的有效性普遍焦虑症的预防.pdfVIP
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protocol for a randomised controlled trial investigating the effectiveness of an online e health application for the prevention of generalised anxiety disorder协议为随机对照试验对在线e健康应用程序的有效性普遍焦虑症的预防
Christensen et al. BMC Psychiatry 2010, 10:25
/1471-244X/10/25
STUDY PROTOCOL Open Access
Protocol for a randomised controlled trial
investigating the effectiveness of an online
e health application for the prevention of
Generalised Anxiety Disorder
1* 1 2 1 1
Helen Christensen , Kathleen M Griffiths , Andrew J Mackinnon , Kanupriya Kalia , Philip J Batterham ,
3 4 1
Justin Kenardy , Claire Eagleson , Kylie Bennett
Abstract
Background: Generalised Anxiety Disorder (GAD) is a highly prevalent psychiatric disorder. Effective prevention in
young adulthood has the potential to reduce the prevalence of the disorder, to reduce disability and lower the
costs of the disorder to the community. The present trial (the WebGAD trial) aims to evaluate the effectiveness of
an evidence-based online prevention website for GAD.
Methods/Design: The principal clinical question under investigation is the effectiveness of an online GAD
intervention (E-couch) using a community-based sample. We examine whether the effect of the intervention can
be maximised by either human support, in the form of telephone calls, or by automated support through emails.
The primary outcome will be a reduction in symptoms on the GAD-7 in the active arms relative to the non active
intervention arms.
Discussion: The WebGAD trial will be the first to evaluate the use of an internet-based cognitive behavioural
therapy (CBT) program contrasted with a credible control condition for the prevention of GAD and the first formal
RCT evaluation of a web-based program for GAD using community recruitment. In general, internet-based CBT
programs have been shown to be effective for the treatment of
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