原创力文档problem-solving versus cognitive restructuring of medically ill seniors with depression (promise-d trial) study protocol and design解决问题与疾病老年人认知重组与抑郁症(promise-d试验)研究方案和设计.pdfVIP
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problem-solving versus cognitive restructuring of medically ill seniors with depression (promise-d trial) study protocol and design解决问题与疾病老年人认知重组与抑郁症(promise-d试验)研究方案和设计
Sharpe et al. BMC Psychiatry 2012, 12:207
/1471-244X/12/207
STUDY PROTOCOL Open Access
Problem-solving versus cognitive restructuring of
medically ill seniors with depression
(PROMISE-D trial): study protocol and design
1* 1 2 3,4 5 6
Louise Sharpe , Catherine B Gittins , Helen M Correia , Tanya Meade , Michael K Nicholas , Patrick J Raue ,
Sarah McDonald1 and Patricia A Areán7
Abstract
Background: With an ageing population in most Western countries, people are living longer but often with one or
more chronic physical health problems. Older people in physically poor health are at greater risk of developing
clinical depression. Cognitive Behavioural Therapy (CBT) and Problem Solving Therapy (PST) have both been found
to be efficacious in treating late-life depression, however patients with “multi-morbidity” (i.e. more than one chronic
condition) are often excluded from these trials. The aim of this study is to compare the efficacy of CBT and PST in
treating older adults who have one or more chronic physical health conditions and a diagnosable depressive
disorder. This study will be the first to explicitly target the treatment of depression in older people in primary care
settings presenting with a range of health problems using behavioural interventions.
Methods/design: The PROMISE-D study is a randomised controlled trial of two evidence-based treatments for
late-life major or minor depression for patients who also have at least one co-morbid chronic health problem.
Participants will be randomised to two active interventions (PST or CBT) or enhanced treatment-as-usual (E-TAU).
Primary outcomes will be depression diagnostic status and severity of depression (according to the Hamilton
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