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proteomics studies confirm the presence of alternative protein isoforms on a large scale蛋白质组学研究证实大规模替代蛋白亚型的存在.pdf

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proteomics studies confirm the presence of alternative protein isoforms on a large scale蛋白质组学研究证实大规模替代蛋白亚型的存在

Volume 9, Issue 11, Article R162Tresset al.2008 Open Access Research Proteomics studies confirm the presence of alternative protein isoforms on a large scale * † †‡§¶ Michael L Tress , Bernd Bodenmiller , Ruedi Aebersold and Alfonso Valencia* Addresses: *Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), C. Melchor Fernandez Almagro, Madrid 28029, Spain. †Institute of Molecular Systems Biology, ETH, Wolfgang-Pauli-Str., 8093 Zurich, Switzerland. ‡Institute for Systems Biology, Seattle, WA 98103, USA. §Competence Center for Systems Physiology and Metabolic Diseases, ETH Zurich, 8093 Zurich, Switzerland. ¶Faculty of Science, University of Zurich, 8057 Zurich, Switzerland. Correspondence: Michael L Tress. Email: mtress@cnio.es Published: 18 November 2008 Received: 13 June 2008 Revised: 29 September 2008 Genome Biology 2008, 9:R162 (doi:10.1186/gb-2008-9-11-r162) Accepted: 18 November 2008 The electronic version of this article is the complete one and can be found online at /2008/9/11/R162 © 2008 Tress et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Proteomic analysis of alternative splicingpStably expressed alternatively-spliced protein isoforms are produced on a genome-wide scale in Drosophila./p Abst