proton-pump inhibitors are associated with a reduced risk for bleeding and perforated gastroduodenal ulcers attributable to non-steroidal anti-inflammatory drugs a nested case-control study服用ppi抑制剂与出血和穿孔的风险降低胃十二指肠溃疡归因于非甾体抗炎药的一个嵌套病例对照研究.pdfVIP

Available online /content/9/3/R52 Vol 9 No 3 Open Access Research article Proton-pump inhibitors are associated with a reduced risk for bleeding and perforated gastroduodenal ulcers attributable to non-steroidal anti-inflammatory drugs: a nested case-control study 1 2 3 4 Harald E Vonkeman , Robert W Fernandes , Job van der Palen , Eric N van Roon and Mart AFJ van de Laar1 1Department of Rheumatology and Clinical Immunology, Medisch Spectrum Twente Hospital and University of Twente, Ariensplein 1, 7500 KA, Enschede, The Netherlands 2Stroinkslanden Pharmacy, Veldhoflanden 90, 7542 LX, Enschede, The Netherlands 3Department of Clinical Epidemiology and Statistics, Medisch Spectrum Twente Hospital, Haaksbergerstraat 55, 7500 KA, Enschede, The Netherlands 4Department of Clinical Pharmacy and Clinical Pharmacology, Medisch Centrum Leeuwarden, Henri Dunantweg 2, 8934 AD, Leeuwarden, The Netherlands Corresponding author: Harald E Vonkeman, h.vonkeman@ziekenhuis-mst.nl Received: 11 Feb 2007 Revisions requested: 16 Apr 2007 Revisions received: 28 Apr 2007 Accepted: 23 May 2007 Published: 23 May 2007 Arthritis Research Therapy 2007, 9:R52 (doi:10.1186/ar2207) This article is online at: /content/9/3/R52 © 2007 Vonkeman et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Treatment with non-steroidal anti-inflammatory drugs (NSAIDs) During the observational peri