原创力文档rankl synthesized by articular chondrocytes contributes to juxta-articular bone loss in chronic arthritis关节软骨细胞rankl合成了导致近关节的骨质流失在慢性关节炎.pdfVIP
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rankl synthesized by articular chondrocytes contributes to juxta-articular bone loss in chronic arthritis关节软骨细胞rankl合成了导致近关节的骨质流失在慢性关节炎
Martínez-Calatrava et al. Arthritis Research Therapy 2012, 14:R149
/content/14/3/R149
RESEARCH ARTICLE Open Access
RANKL synthesized by articular chondrocytes
contributes to juxta-articular bone loss in chronic
arthritis
Maria J Martínez-Calatrava, Ivan Prieto-Potín, Jorge A Roman-Blas, Lidia Tardio, Raquel Largo and
*
Gabriel Herrero-Beaumont
Abstract
Introduction: The receptor activator nuclear factor-kappaB ligand (RANKL) diffuses from articular cartilage to
subchondral bone. However, the role of chondrocyte-synthesized RANKL in rheumatoid arthritis-associated juxta-
articular bone loss has not yet been explored. This study aimed to determine whether RANKL produced by
chondrocytes induces osteoclastogenesis and juxta-articular bone loss associated with chronic arthritis.
Methods: Chronic antigen-induced arthritis (AIA) was induced in New Zealand (NZ) rabbits. Osteoarthritis (OA) and
control groups were simultaneously studied. Dual X-ray absorptiometry of subchondral knee bone was performed
before sacrifice. Histological analysis and protein expression of RANKL and osteoprotegerin (OPG) were evaluated in
joint tissues. Co-cultures of human OA articular chondrocytes with peripheral blood mononuclear cells (PBMCs)
from healthy donors were stimulated with macrophage-colony stimulating factor (M-CSF) and prostaglandin E2
(PGE ), then further stained with tartrate-resistant acid phosphatase.
2
Results: Subchondral bone loss was confirmed in AIA rabbits when compared with controls. The expression of
RANKL, OPG and RANKL/OPG ratio in cartilage were increased in AIA compared to control animals, although this
pattern was not seen in synovium. Furthermore, RANKL expression and RANKL/OPG ratio were inversely related to
subchondral bone mineral density. RANKL expression was observe
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