recombination in avian gamma-coronavirus infectious bronchitis virus重组禽gamma-coronavirus传染性支气管炎病毒.pdfVIP

Viruses 2011, 3, 1777-1799; doi:10.3390/v3091777 OPEN ACCESS viruses ISSN 1999-4915 /journal/viruses Article Recombination in Avian Gamma-Coronavirus Infectious Bronchitis Virus 1 1 2 3 Sharmi W. Thor , Deborah A. Hilt , Jessica C. Kissinger , Andrew H. Paterson and Mark W. Jackwood 1,* 1 Department of Population Health, Poultry Diagnostic and Research Center, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA; E-Mails: sthor@ (S.W.T.); dhilt@ (D.A.H.) 2 Department of Genetics, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA; E-Mail: jkissing@ 3 Plant Genome Mapping Laboratory, Departments of Crop and Soil Sciences, Plant Biology and Genetics, University of Georgia, Athens, GA 30602, USA; E-Mail: paterson@ * Author to whom correspondence should be addressed; E-Mail: mjackwoo@; Tel.: +1-706-542-5475; Fax: +1-706-542-5630. Received: 8 August 2011; in revised form: 24 August 2011 / Accepted: 5 September 2011 / Published: 23 September 2011 Abstract: Recombination in the family Coronaviridae has been well documented and is thought to be a contributing factor in the emergence and evolution of different coronaviral genotypes as well as different species of coronavirus. However, there are limited data available on the frequency and extent of recombination in coronaviruses in nature and p