reduced animal model for marker assisted selection using best linear unbiased prediction降低了分子标记辅助选择动物模型利用最佳线性无偏预测.pdfVIP

Original article Reduced animal model for marker assisted selection using best linear unbiased prediction RJC Cantet* C Smith University of Guelpla, Centre for Genetic rovementImPof Livestock, Department of Animal and I’oultry Science, Guelph, Ontario, N1G 2Wl, Canada (Received 15 October 1990; accepted 11 April 1991) Summary - A reduced animal model (RAM)version of the animal model (AM) incorpo- rating independent marked quantitative trait loci (M(aTL’s) of Fernando and Grossman (1989) is presented. Both AM and RAM permit obtaining Best Linear Unbiased Pre- dictions of MQTL effects plus the remaining portion of the breeding value that is not accounted for by independent M(aTL’s. RAM reduces computational requirements by a reduction in the size of the system of equations. Non-parental MQTL effects are ex- pressed as a linear function of parental MQTL effects using marker information and the recombination rate (r) between the marker locus and the MQTL. The resulting fraction of the MQTL variance that is explained by the regression on parental MQTL effects is 2[(1- r)2] /2+ r2when the individual is not inbred and both parents are known. Formulae are obtained to simplify the computations when backsolving for non-parental MQTL and breeding values in case all non-parents have one record. A small numerical example is also presented. maker assisted selection / best linear unbiased prediction / reduced animal model / genetic marker Résumé - Un modèle animal réduit la sélection assistée avec pour par marqueurs BLUP. Une version du ncodèle animal réduit (RAM)basée sur le modèle animal (AM) de Fernando et Crossman (1989) avec loci indépendants de caractères quant