reduced duration mismatch negativity in adolescents with psychotic symptoms further evidence for mismatch negativity as a possible biomarker for vulnerability to psychosis进一步减少持续时间不匹配消极在青少年精神病症状的证据不匹配消极作为易受精神病的可能的生物标志物.pdfVIP

Murphy et al. BMC Psychiatry 2013, 13:45 /1471-244X/13/45 RESEARCH ARTICLE Open Access Reduced duration mismatch negativity in adolescents with psychotic symptoms: further evidence for mismatch negativity as a possible biomarker for vulnerability to psychosis 1,2 1 2 2 2 2,3*† Jennifer R Murphy , Caroline Rawdon , Ian Kelleher , Deirdre Twomey , Patrick S Markey , Mary Cannon and Richard AP Roche1† Abstract Background: Deficits in the mismatch negativity (MMN) and P3a components are the most reliable and robust findings in schizophrenia. These abnormalities have also been recently documented in individuals clinically at risk for psychosis, indicating that the MMN may be a potential biomarker for psychosis. However, the at risk samples included in MMN studies are characterised by pre-existing clinical symptomatology and significant functional decline which are related to MMN amplitude. These factors may be potential confounds in determining whether deficient MMN is present prior to clinical manifestation of the disorder. Therefore, investigating the MMN in the extended psychosis phenotype comprising adolescents with psychotic symptoms from the general population may provide important information on whether abnormal MMN is apparent in the earliest stages of risk. Methods: Thirty six adolescents completed a duration deviant MMN task. Fourteen adolescents with psychotic symptoms comprised the at risk group and 22 with no psychotic symptoms comprised the Controls. The task consisted of 85% standard tones (25 ms) and 15% deviant tones (50 ms). The groups were compared on MMN and P3a amplitude and latency across frontocentral and temporal electrodes. Results: Adolescents with psychotic symptoms were cha