原创力文档reduced immunomodulation potential of bone marrow-derived mesenchymal stem cells induced ccr4+ccr6+ thtreg cell subset imbalance in ankylosing spondylitis减少潜在的免疫调节骨骨髓来源间充质干细胞诱导ccr4 + ccr6 + thtreg细胞失衡强直性脊柱炎子集.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
reducedimmunomodulationpotentialofbonemarrow-derivedmesenchymalstemcellsinducedccr4ccr6thtregcellsubsetimbalanceinankylosingspondylitis减少潜在的免疫调节骨骨髓来源间充质干细胞诱导ccr4ccr6thtreg细胞失衡强直性脊柱炎子集
Wu et al. Arthritis Research Therapy 2011, 13:R29
/content/13/1/R29
RESEARCH ARTICLE Open Access
Reduced immunomodulation potential of bone
marrow-derived mesenchymal stem cells induced
CCR4+CCR6+ Th/Treg cell subset imbalance in
ankylosing spondylitis
1† 2† 2 2 3 2 2 2
Yanfeng Wu , Mingliang Ren , Rui Yang , Xinjun Liang , Yuanchen Ma , Yong Tang , Lin Huang , Jichao Ye ,
Keng Chen2, Peng Wang2*, Huiyong Shen2*
Abstract
Introduction: Ankylosing spondylitis (AS) is a chronic autoimmune disease, and the precise pathogenesis is largely
unknown at present. Bone marrow-derived mesenchymal stem cells (BMSCs) with immunosuppressive and anti-
inflammatory potential and Th17/Treg cells with a reciprocal relationship regulated by BMSCs have been reported
to be involved in some autoimmune disorders. Here we studied the biological and immunological characteristics
of BMSCs, the frequency and phenotype of CCR4+CCR6+ Th/Treg cells and their interaction in vitro in AS.
Methods: The biological and immunomodulation characteristics of BMSCs were examined by induced multiple-
differentiation and two-way mixed peripheral blood mononuclear cell (PBMC) reactions or after stimulation with
phytohemagglutinin, respectively. The interactions of BMSCs and PBMCs were detected with a direct-contact co-
culturing system. CCR4+CCR6+ Th/Treg cells and surface markers of BMSCs were assayed using flow cytometry.
Results: The AS-BMSCs at active stage showed normal proliferation, cell viability, surface markers and multiple
differentiation characteristics, but significantly reduced immunomodulation potential (decreased 68 ± 14%); the
+ +
您可能关注的文档
- range and velocity estimation of moving targets using multiple stepped-frequency pulse trains移动目标的范围和速度估计使用多个stepped-frequency脉冲列车.pdf
- randomized trial comparing daily interruption of sedation and nursing-implemented sedation algorithm in medical intensive care unit patients随机试验比较日常中断镇静和nursing-implemented镇静算法在医学重症监护室的病人.pdf
- ranking genes with respect to differential expression排名基因对微分表达式.pdf
- randomized trial evaluating serial protein c levels in severe sepsis patients treated with variable doses of drotrecogin alfa (activated)随机试验评估连环蛋白c水平严重脓毒症患者可变剂量的drotrecogin阿尔法(激活).pdf
- ranking differentially expressed genes from affymetrix gene expression data methods with reproducibility, sensitivity, and specificity排名从affymetrix基因表达数据的差异表达基因的方法重现性、灵敏度和特异性.pdf
- randomized trial of achieving healthy lifestyles in psychiatric rehabilitation the achieve trial随机试验的实现精神康复的健康生活方式实现审判.pdf
- randomized, placebo-controlled, double-blind trial of swedish snus for smoking reduction and cessation随机、安慰剂对照、双盲试验的瑞典鼻烟减少吸烟和戒烟.pdf
- rapamycin and mtor a serendipitous discovery and implications for breast cancer雷帕霉素和mtor偶然的发现和对乳腺癌的影响.pdf
- range camera self-calibration based on integrated bundle adjustment via joint setup with a 2d digital camera相机自校准范围基于集成包调整通过联合设置一个2 d数码相机.pdf
- rapid and accurate pyrosequencing of angiosperm plastid genomes快速和准确的焦磷酸测序的被子植物质体基因组.pdf
- reduced selection leads to accelerated gene loss in shigella志贺氏杆菌减少选择导致加速基因损失.pdf
- reducing dimensionality for prediction of genome-wide breeding values预测减少维数的全基因组育种值.pdf
- reduced transforming growth factor-beta signaling in cartilage of old mice role in impaired repair capacity减少转化生长因子信号在软骨的老老鼠受损修复能力的作用.pdf
- reducing energy subsidies in china, india and russia dilemmas for decision makers减少能源补贴在中国、印度和俄罗斯决策者的难题.pdf
- reducing harm from hivaids misconceptions among female sex workers in tijuana and ciudad juarez, mexico a cross sectional analysis减少伤害的条件之间的误解女性性工作者在提华纳和华雷斯城,墨西哥一个横截面分析.pdf
- reducing false negative reads in rfid data streams using an adaptive sliding-window approach减少假阴性读取rfid数据流使用一个自适应滑动窗口的方法.pdf
- reduced reliance on the trace element selenium during evolution of mammals减少依赖微量元素硒在哺乳动物的进化.pdf
- reducing errors in health care cost-effectiveness of multidisciplinary team training in obstetric emergencies (tosti study); a randomised controlled trial减少错误在卫生保健成本效益的多学科团队训练在产科紧急情况(tosti研究);.pdf
- reducing sodium in foods the effect on flavor减少钠盐在食品风味的影响.pdf
- reducing mortality in sepsis new directions降低死亡率在脓毒症的新方向.pdf
文档评论（0）