reduced transforming growth factor-beta signaling in cartilage of old mice role in impaired repair capacity减少转化生长因子信号在软骨的老老鼠受损修复能力的作用.pdfVIP

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reduced transforming growth factor-beta signaling in cartilage of old mice role in impaired repair capacity减少转化生长因子信号在软骨的老老鼠受损修复能力的作用.pdf

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reduced transforming growth factor-beta signaling in cartilage of old mice role in impaired repair capacity减少转化生长因子信号在软骨的老老鼠受损修复能力的作用

Available online /content/7/6/R1338 Vol 7 No 6 Open Access Research article Reduced transforming growth factor-beta signaling in cartilage of old mice: role in impaired repair capacity EN Blaney Davidson, A Scharstuhl, EL Vitters, PM van der Kraan and WB van den Berg Experimental Rheumatology and Advanced Therapeutics, St Radboud University Medical Centre Nijmegen, Geert Grooteplein 26, 6525 GA Nijmegen, The Netherlands Corresponding author: PM van der Kraan, p.vanderkraan@reuma.umcn.nl Received: 4 Jul 2005 Revisions requested: 26 Jul 2005 Revisions received: 18 Aug 2005 Accepted: 1 Sep 2005 Published: 30 Sep 2005 Arthritis Research Therapy 2005, 7:R1338-R1347 (DOI 10.1186/ar1833) This article is online at: /content/7/6/R1338 © 2005 Blaney Davidson et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/ 2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Osteoarthritis (OA) is a common joint disease, mainly effecting injected. Proteoglycan (PG) synthesis (35S-sulfate the elderly population. The cause of OA seems to be an incorporation) and PG content of the cartilage were determined. imbalance in catabolic and anabolic factors that develops with Our experiments revealed that TGF-beta2 and -3 expression age. IL-1 is a catabolic factor known to induce cartilage damage, decreased with age, as did the TGF-beta receptors. Although and transforming growth factor (TGF)-beta is an anabolic factor the number of cells positiv