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reduced reliance on the trace element selenium during evolution of mammals减少依赖微量元素硒在哺乳动物的进化.pdf

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reduced reliance on the trace element selenium during evolution of mammals减少依赖微量元素硒在哺乳动物的进化

Volume 9, Issue 3, Article R62et al.Lobanov2008 Open Access Research Reduced reliance on the trace element selenium during evolution of mammals * † * Alexey V Lobanov , Dolph L Hatfield and Vadim N Gladyshev Addresses: *Department of Biochemistry, University of Nebraska, Lincoln, NE 68588, USA. †Section on the Molecular Biology of Selenium, Laboratory of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Correspondence: Vadim N Gladyshev. Email: vgladyshev1@ Published: 31 March 2008 Received: 10 January 2008 Revised: 5 March 2008 Genome Biology 2008, 9:R62 (doi:10.1186/gb-2008-9-3-r62) Accepted: 31 March 2008 The electronic version of this article is the complete one and can be found online at /2008/9/3/R62 © 2008 Lobanov et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. dietary supplements when pathReliance on selenium during evolutionpEvolution from fish to mammals was accoology is not imminent./pmpanied by decreased use of selenocysteine, raising questions about the need for selenium Abstract Background: Selenium (Se) is an essential trace element that occurs in proteins in the form of selenocysteine (Sec). It is transported throughout the body in the form of Sec residues in