reducing mortality in severe sepsis with the implementation of a core 6-hour bundle results from the portuguese community-acquired sepsis study (saciuci study)降低死亡率在严重脓毒症的实现核心长达6包从葡萄牙社区获得性脓毒症研究的结果(saciuci研究).pdfVIP

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reducing mortality in severe sepsis with the implementation of a core 6-hour bundle results from the portuguese community-acquired sepsis study (saciuci study)降低死亡率在严重脓毒症的实现核心长达6包从葡萄牙社区获得性脓毒症研究的结果(saciuci研究).pdf

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reducing mortality in severe sepsis with the implementation of a core 6-hour bundle results from the portuguese community-acquired sepsis study (saciuci study)降低死亡率在严重脓毒症的实现核心长达6包从葡萄牙社区获得性脓毒症研究的结果(saciuci研究)

Cardoso et al. Critical Care 2010, 14:R83 /content/14/3/R83 R E S E A R C H Open Access Research Reducing mortality in severe sepsis with the implementation of a core 6-hour bundle: results from the Portuguese community-acquired sepsis study (SACiUCI study) 1 1 2 2 Teresa Cardoso* , António Henriques Carneiro , Orquídea Ribeiro , Armando Teixeira-Pinto and Altamiro Costa- Pereira2 Abstract Introduction: To evaluate the impact of compliance with a core version of the Surviving Sepsis Campaign 6-hour bundle on 28 days mortality. Methods: Cohort, multi-centre, prospective study on community-acquired sepsis (CAS). Results: Seventeen intensive care units (ICU) entered the study. Over a one year period, 4,142 patients were enrolled in the study. Of the 897 (24%) admitted with CAS, 778 (87%) had severe sepsis or septic shock on ICU admission. In the first six hours of hospital admission: (1) 62% had serum lactate measured; (2) 69% fluids administered; (3) 77% specimens collected for microbiology before antibiotic administration; (4) 48% blood cultures obtained; (5) 52% antibiotics administered within the first hour of the diagnosis; (6) vasopressors were given in 78%; (7) 56% had central venous measurement (CVP) measurement; (8) 17% had a central venous oxygen saturation (ScvO2) measurement; (9) dobutamine was administered in 52%. Compliance with all actions 1 to 6 (core bundle) was associated with an odds ratio (OR) of 0.44 [95% confidence interval (CI) = 0.24-0.80] in severe sepsis and 0.49 (95% CI = 0.25-0.95) in septic shock, for 28 days mortality. This corresponded to a number needed to treat of 6 patients to save one life. Conclusions: Compliance with this core bundle was associated with a signific