reduced trabecular bone mineral density and cortical thickness accompanied by increased outer bone circumference in metacarpal bone of rheumatoid arthritis patients a cross-sectional study减少小梁骨矿物质密度和皮质厚度伴随着掌骨骨外骨周长增加类风湿性关节炎患者的横断面研究.pdfVIP

Aeberli et al. Arthritis Research Therapy 2010, 12:R119 /content/12/3/R119 R E S E A R C H A R T I C L E Open Access Research article Reduced trabecular bone mineral density and cortical thickness accompanied by increased outer bone circumference in metacarpal bone of rheumatoid arthritis patients: a cross-sectional study †1 †1 2 1 1 1 1 Daniel Aeberli* , Prisca Eser , Harald Bonel , Jolanda Widmer , Gion Caliezi , Pierre-Alain Varisco , Burkhard Möller and Peter M Villiger1 Abstract Introduction: The objective of this study was to assess three-dime nsional bone geometry and density at the epiphysis and shaft of the third meta-carpal bone of rheumatoid arthritis (RA) patients in comparison to healthy controls with the novel method of peripheral quantitative computed tomography (pQCT). Methods: PQCT scans were performed in 50 female RA patients and 100 healthy female controls at the distal epiphyses and shafts of the third metacarpal bone, the radius and the tibia. Reproducibility was determined by coefficient of varia-tion. Bone densitometric and geometric parameters were compared between the two groups and correlated to disease characteristics. Results: Reproducibility of different pQCT parameters was between 0.7% and 2.5%. RA patients had 12% to 19% lower trabecular bone mineral density (BMD) (P ≤ 0.001) at the distal epiphyses of radius, tibia and metacarpal bone. At the shafts of these bones RA patients had 7% to 16% thinner cortices (P ≤ 0.03). Total cross-sectional area (CSA) at the metacarpal bone shaft of pa-tients was larger (between 5% and 7%, P 0.02), and relative cortical area was reduced by 13%. Erosiveness by Ratingen score correlated negatively with tra-becular and total