原创力文档regulation of excitation-contraction coupling in mouse cardiac myocytes integrative analysis with mathematical modelling监管的老鼠心脏细胞的兴奋收缩偶联综合分析与数学建模.pdfVIP
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regulation of excitation-contraction coupling in mouse cardiac myocytes integrative analysis with mathematical modelling监管的老鼠心脏细胞的兴奋收缩偶联综合分析与数学建模
BMC Physiology BioMed Central
Research article Open Access
Regulation of excitation-contraction coupling in mouse cardiac
myocytes: integrative analysis with mathematical modelling
†1 †2 1 1
Jussi T Koivumäki , Topi Korhonen , Jouni Takalo , Matti Weckström and
Pasi Tavi*2
Address: 1Department of Physics, University of Oulu Biocenter Oulu, Finland and 2Department of Biotechnology and Molecular Medicine, A.I.
Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland
Email: Jussi T Koivumäki - jussi.koivumaki@oulu.fi; Topi Korhonen - topi.korhonen@uku.fi; Jouni Takalo - jouni.takalo@oulu.fi;
Matti Weckström - matti.weckstrom@oulu.fi; Pasi Tavi* - pasi.tavi@uku.fi
* Corresponding author †Equal contributors
Published: 31 August 2009 Received: 25 June 2009
Accepted: 31 August 2009
BMC Physiology 2009, 9:16 doi:10.1186/1472-6793-9-16
This article is available from: /1472-6793/9/16
© 2009 Koivumäki et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: The cardiomyocyte is a prime example of inherently complex biological system with
inter- and cross-connected feedback loops in signalling, forming the basic properties
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