原创力文档recent findings concerning pamam dendrimer conjugates with cyclodextrins as carriers of dna and rna最近发现关于pamam树形分子与环糊精轭合物作为dna和rna的运营商.pdfVIP
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recent findings concerning pamam dendrimer conjugates with cyclodextrins as carriers of dna and rna最近发现关于pamam树形分子与环糊精轭合物作为dna和rna的运营商
Sensors 2009, 9, 6346-6361; doi:10.3390/
OPEN ACCESS
sensors
ISSN 1424-8220
/journal/sensors
Review
Recent Findings Concerning PAMAM Dendrimer Conjugates
with Cyclodextrins as Carriers of DNA and RNA
Hidetoshi Arima * and Keiichi Motoyama
Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto
862-0973, Japan; E-Mail: motoyama@kumamoto-u.ac.jp (K.M.)
* Author to whom correspondence should be addressed; E-Mail: arimah@gpo.kumamoto-u.ac.jp;
Tel.: +81-96-371-4160; Fax: +81-96-371-4420
Received: 2 July 2009; in revised form: 6 August 2009 / Accepted: 7 August 2009 /
Published: 17 August 2009
Abstract: We have evaluated the potential use of various polyamidoamine (PAMAM)
dendrimer [dendrimer, generation (G) 2-4] conjugates with cyclodextrins (CyDs) as novel
DNA and RNA carriers. Among the various dendrimer conjugates with CyDs, the
dendrimer (G3) conjugate with -CyD having an average degree of substitution (DS) of
2.4 [-CDE (G3, DS2)] displayed remarkable properties as DNA, shRNA and siRNA
delivery carriers through the sensor function of -CDEs toward nucleic acid drugs, cell
surface and endosomal membranes. In an attempt to develop cell-specific gene transfer
carriers, we prepared sugar-appended -CDEs. Of the various sugar-appended -CDEs
prepared, galactose- or mannose-appended -CDEs provided superior gene transfer
activity to -C
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