quantitation of glucose uptake in tumors by dynamic fdg-pet has less glucose bias and lower variability when adjusted for partial saturation of glucose transport定量的葡萄糖吸收的肿瘤动态正减少葡萄糖偏见和低变异性部分饱和的葡萄糖运输调整后).pdfVIP

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quantitation of glucose uptake in tumors by dynamic fdg-pet has less glucose bias and lower variability when adjusted for partial saturation of glucose transport定量的葡萄糖吸收的肿瘤动态正减少葡萄糖偏见和低变异性部分饱和的葡萄糖运输调整后).pdf

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quantitation of glucose uptake in tumors by dynamic fdg-pet has less glucose bias and lower variability when adjusted for partial saturation of glucose transport定量的葡萄糖吸收的肿瘤动态正减少葡萄糖偏见和低变异性部分饱和的葡萄糖运输调整后)

Williams et al. EJNMMI Research 2012, 2:6 /content/2/1/6 ORIGINAL RESEARCH Open Access Quantitation of glucose uptake in tumors by dynamic FDG-PET has less glucose bias and lower variability when adjusted for partial saturation of glucose transport 1* 1 2 3* Simon-Peter Williams , Judith E Flores-Mercado , Ruediger E Port and Thomas Bengtsson Abstract Background: A retrospective analysis of estimates of tumor glucose uptake from 1,192 dynamic 2-deoxy-2-(18F) fluoro-D-glucose-positron-emission tomography [FDG-PET] scans showed strong correlations between blood glucose and both the uptake rate constant [Ki] and the metabolic rate of glucose [MRGluc], hindering the interpretation of PET scans acquired under conditions of altered blood glucose. We sought a method to reduce this glucose bias without increasing the between-subject or test-retest variability and did this by considering that tissue glucose transport is a saturable yet unsaturated process best described as a nonlinear function of glucose levels. Methods: Patlak-Gjedde analysis was used to compute Ki from 30-min dynamic PET scans in tumor-bearing mice. MRGluc was calculated by factoring in the blood glucose level and a lumped constant equal to unity. Alternatively, we assumed that glucose consumption is saturable according to Michaelis-Menten kinetics and estimated a hypothetical maximum rate of glucose consumption [MRGlucMAX] by multiplying K and (K + [glucose]), where K i M M is a half-saturation Michaelis constant for glucose uptake. Results were computed for 112 separate studies o