quantification of the whole-body burden of radiographic osteoarthritis using factor analysis量化的全身骨关节炎影像学使用因子分析的负担.pdfVIP

Nelson et al. Arthritis Research Therapy 2011, 13:R176 /content/13/5/R176 RESEARCH ARTICLE Open Access Quantification of the whole-body burden of radiographic osteoarthritis using factor analysis 1* 1,2 1,3 1,4 5 Amanda E Nelson , Robert F DeVellis , Jordan B Renner , Todd A Schwartz , Philip G Conaghan , Virginia B Kraus6 and Joanne M Jordan1 Abstract Introduction: Although osteoarthritis (OA) commonly involves multiple joints, no widely accepted method for quantifying whole-body OA burden exists. Therefore, our aim was to apply factor analytic methods to radiographic OA (rOA) grades across multiple joint sites, representing both presence and severity, to quantify the burden of rOA. Methods: We used cross-sectional data from the Johnston County Osteoarthritis Project. The sample (n = 2092) had a mean age of 65 ± 11 years, body mass index (BMI) 31 ± 7 kg/m2, with 33% men and 34% African Americans. A single expert reader (intra-rater = 0.89) provided radiographic grades based on standard atlases for the hands (30 joints, including bilateral distal and proximal interphalangeal [IP], thumb IP, metacarpophalangeal [MCP] and carpometacarpal [CMC] joints), knees (patellofemoral and tibiofemoral, 4 joints), hips (2 joints), and spine (5 levels [L1/2 to L5/S1]). All grades were entered into an exploratory common factor analysis as continuous variables. Stratified factor analyses were used to look for differences by gender, race, age, and cohort subgroups. Results: Four factors were identified as follows: IP/CMC factor (20 joints), MCP factor (8 joints), Knee factor (4 joints), Spine factor (5 levels). These factors had high internal consistency reliability (Cronbach ’s a range 0