prospectively validated predictions of shock and organ failure in individual septic surgical patients the systemic mediator associated response test前瞻性验证预测个人脓毒性休克和器官衰竭的外科病人相关的系统性中介响应测试.pdfVIP
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prospectively validated predictions of shock and organ failure in individual septic surgical patients the systemic mediator associated response test前瞻性验证预测个人脓毒性休克和器官衰竭的外科病人相关的系统性中介响应测试
/content/4/5/319
Primary research
Prospectively validated predictions of shock and organ failure in
individual septic surgical patients: the Systemic Mediator
Associated Response Test
Gus J Slotman
University of Medicine and Dentistry of New Jersey, Camden, New Jersey, USA
Received: 23 December 1999 2000 Crit Care 2000, 4:319–326
Revisions requested: 16 May 2000
The electronic version of this article can be found online at
Revisions received: 17 July 2000
/content/4/5/319
Accepted: 31 July 2000
Published: 8 September 2000 © Current Science Ltd (Print ISSN 1364-8535; Online ISSN 1466-609X)
Abstract
Introduction: Clinically useful predictions of end-organ function and failure in severe sepsis
may be possible through analyzing the interactions among demographics, physiologic
parameters, standard laboratory tests, and circulating markers of inflammation. The present
study evaluated the ability of such a methodology, the Systemic Mediator Associated
Response Test (SMART), to predict the clinical course of septic surgery patients from a
database of medical and surgical patients with severe sepsis and/or septic shock.
Patients and methods: Three hundred and three patients entered into the placebo arm of a
multi-institutional sepsis study were randomly assigned to a model-building cohort (n = 200;
119 surgical) or to a predictive cohort (n = 103; 55 surgical). Using baseline and baseline
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