原创力文档previous hospital admissions and disease severity predict the use of antipsychotic combination treatment in patients with schizophrenia之前的住院和疾病严重程度预测使用抗精神病药物联合治疗的精神分裂症患者.pdfVIP
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previous hospital admissions and disease severity predict the use of antipsychotic combination treatment in patients with schizophrenia之前的住院和疾病严重程度预测使用抗精神病药物联合治疗的精神分裂症患者
Bolstad et al. BMC Psychiatry 2011, 11:126
/1471-244X/11/126
RESEARCH ARTICLE Open Access
Previous hospital admissions and disease severity
predict the use of antipsychotic combination
treatment in patients with schizophrenia
Albert Bolstad1*, Ole A Andreassen2,3, Jan I Røssberg2,3, Ingrid Agartz1,2, Ingrid Melle2,3 and Lars Tanum3,4
Abstract
Background: Although not recommended in treatment guidelines, previous studies have shown a frequent use of
more than one antipsychotic agent among patients with schizophrenia. The main aims of the present study were
to explore the antipsychotic treatment regimen among patients with schizophrenia in a catchment area-based
sample and to investigate clinical characteristics associated with antipsychotic combination treatment.
Methods: The study included 329 patients diagnosed with schizophrenia using antipsychotic medication. Patients
were recruited from all psychiatric hospitals in Oslo. Diagnoses were obtained by use of the Structured Clinical
Interview for DSM-IV Axis I disorders (SCID-I). Additionally, Global Assessment of Functioning (GAF), Positive and
Negative Syndrome Scale (PANSS) and number of hospitalisations and pharmacological treatment were assessed.
Results: Multiple hospital admissions, low GAF scores and high PANSS scores, were significantly associated with
the prescription of combination treatment with two or more antipsychotics. The use of combination treatment
increased significantly from the second hospital admission. Combination therapy was not significantly associated
with age or gender. Regression models confirmed that an increasing number of hospital admission was the
strongest predictor of the use of two or more antipsychotics.
Conclusions: Previous hospital admissions and disease severity measured by high PANSS scores and low GAF
scores, predict
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