pre-existing disease the most important factor for health related quality of life long-term after critical illness a prospective, longitudinal, multicentre trial预先存在的疾病对健康相关生活质量最重要的因素长期潜在重要的疾病后,纵向,多中心试验.pdfVIP

Orwelius et al. Critical Care 2010, 14:R67 /content/14/2/R67 RESEARCH Open Access Pre-existing disease: the most important factor for health related quality of life long-term after critical illness: a prospective, longitudinal, multicentre trial 1* 2 3 3 4 5 Lotti Orwelius , Anders Nordlund , Peter Nordlund , Eva Simonsson , Carl Bäckman , Anders Samuelsson , Folke Sjöberg6 Abstract Introduction: The aim of the present multicenter study was to assess long term (36 months) health related quality of life in patients after critical illness, compare ICU survivors health related quality of life to that of the general population and examine the impact of pre-existing disease and factors related to ICU care on health related quality of life. Methods: Prospective, longitudinal, multicentre trial in three combined medical and surgical intensive care units of one university and two general hospitals in Sweden. By mailed questionnaires, health related quality of life was assessed at 6, 12, 24 and 36 months after the stay in ICU by EQ-5D and SF-36, and information of pre-existing disease was collected at the 6 months measure. ICU related factors were obtained from the local ICU database. Comorbidity and health related quality of life (EQ-5D; SF-36) was examined in the reference group. Among the 5306 patients admitted, 1663 were considered eligible (24 hrs in the intensive care unit, and age ≥ 18 yrs, and alive 6 months after discharge). At the 6 month measure 980 (59%) patients answered the questionnaire. Of these 739 (75%) also answered at 12 month, 595 (61%) at 24 month, and 478 (47%) answered at the 36 month measure. As reference group, a random sample (n = 6093) of people from the uptake are