原创力文档possible association of norepinephrine transporter -3081(at) polymorphism with methylphenidate response in attention deficit hyperactivity disorder去甲肾上腺素转运体可能协会-3081(在)多态性与注意缺陷多动障碍哌醋甲酯反应.pdfVIP
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possible association of norepinephrine transporter -3081(at) polymorphism with methylphenidate response in attention deficit hyperactivity disorder去甲肾上腺素转运体可能协会-3081(在)多态性与注意缺陷多动障碍哌醋甲酯反应
Kim et al. Behavioral and Brain Functions 2010, 6:57
/content/6/1/57
RESEARCH Open Access
Possible association of norepinephrine
transporter -3081(A/T) polymorphism with
methylphenidate response in attention deficit
hyperactivity disorder
*
Boong-Nyun Kim, Jae-Won Kim , Soon Beom Hong, Soo-Churl Cho, Min-Sup Shin, Hee-Jeong Yoo
Abstract
Background: Attention-deficit/hyperactivity disorder (ADHD) is a heritable disorder characterized by symptoms of
inattention and/or hyperactivity/impulsivity. Methylphenidate (MPH) has been shown to block the norepinephrine
transporter (NET), and genetic investigations have demonstrated that the norepinephrine transporter gene (SLC6A2)
is associated with ADHD. The aims of this study were to examine the association of the SLC6A2 -3081(A/T) and
G1287A polymorphisms with MPH response in ADHD.
Methods: This study enrolled 112 children and adolescents with ADHD. A response criterion was defined based on
the Clinical Global Impression-Improvement (CGI-I) score, and the ADHD Rating Scale-IV (ARS) score was also
assessed at baseline and 8 weeks after MPH treatment.
Results: We found that the subjects who had the T allele as one of the alleles (A/T or T/T genotypes) at the -3081
(A/T) polymorphism showed a better response to MPH treatment than those with the A/A genotype as measured
by the CGI-I. We also found a trend towards a difference in the change of the total ARS scores and hyperactivity/
impulsivity subscores between subjects with and without the T allele. No significant association was found
between the genotypes of the SLC6A2 G1287A polymorphism and response to ADHD treatment.
Conclusion: Our findings provide evidence for the involvement of the -3081(A/T) polymorphism of SLC6A2 in the
modulation of the effectiveness of MPH treatment i
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