possible use of repeated cold stress for reducing fatigue in chronic fatigue syndrome a hypothesis可能使用重复的冷应激减少疲劳在慢性疲劳综合症的假设.pdfVIP
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possible use of repeated cold stress for reducing fatigue in chronic fatigue syndrome a hypothesis可能使用重复的冷应激减少疲劳在慢性疲劳综合症的假设
Behavioral and Brain Functions BioMed Central
Hypothesis Open Access
Possible use of repeated cold stress for reducing fatigue in Chronic
Fatigue Syndrome: a hypothesis
Nikolai A Shevchuk
Address: Molecular Radiobiology Section, the Department of Radiation Oncology, Virginia Commonwealth University School of Medicine, 401
College St, Richmond, VA 23298, USA
Email: Nikolai A Shevchuk - nshevchuk@
Published: 24 October 2007 Received: 5 July 2007
Accepted: 24 October 2007
Behavioral and Brain Functions 2007, 3:55 doi:10.1186/1744-9081-3-55
This article is available from: /content/3/1/55
© 2007 Shevchuk; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Physiological fatigue can be defined as a reduction in the force output and/or energy-
generating capacity of skeletal muscle after exertion, which may manifest itself as an inability to
continue exercise or usual activities at the same intensity. A typical example of a fatigue-related
disorder is chronic fatigue syndrome (CFS), a disabling condition of unknown etiology and with
uncertain therapeutic options. Recent advances in elucidating pathophysiology of this disorder
revealed hypofunction of the hypothalamic-pituitary-adrenal axis and that fatigue in CFS patients
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