原创力文档post cardiac surgery vasoplegia is associated with high preoperative copeptin plasma concentration心脏手术后vasoplegia与高术前copeptin等离子体浓度有关.pdfVIP
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post cardiac surgery vasoplegia is associated with high preoperative copeptin plasma concentration心脏手术后vasoplegia与高术前copeptin等离子体浓度有关
Colson et al. Critical Care 2011, 15:R255
/content/15/5/R255
RESEARCH Open Access
Post cardiac surgery vasoplegia is associated with
high preoperative copeptin plasma concentration
1,2* 1 3 3 4 2
Pascal H Colson , Cedric Bernard , Joachim Struck , Nils G Morgenthaler , Bernard Albat and Gilles Guillon
Abstract
Introduction: Post cardiac surgery vasodilatation (PCSV) is possibly related to a vasopressin deficiency that could
relate to chronic stimulation of adeno-hypophysis. To assess vasopressin system activation, a perioperative course
of copeptin and vasopressin plasma concentrations were studied in consecutive patients operated on for cardiac
surgery.
Methods: Sixty-four consecutive patients scheduled for elective cardiac surgery with cardiopulmonary bypass were
studied. Hemodynamic, laboratory and clinical data were recorded before and during cardiopulmonary bypass, and
at the eighth postoperative hour (H8). At the same time, blood was withdrawn to determine plasma
concentrations of arginine vasopressin (AVP, radioimmunoassay) and copeptin (immunoluminometric assay). PCSV
was defined as mean arterial blood pressure 60 mmHg with cardiac index ≥ 2.2 l/min/m2, and was treated with
norepinephrine to restore mean blood pressure 60 mmHg. Patients with PCSV were compared with the other
patients (controls). Student’s t test, Fisher’s exact test, or nonparametric tests (Mann-Whitney, Wilcoxon) were used
when appropriate. Correlation between AVP and copeptin was evaluated and receiver-operator characteristic
analysis assessed the utility of preoperative copeptin to distinguish between controls and PCSV patients.
Results: Patients who experienced PCSV had significa
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