plasma concentrations of soluble cytokine receptors in euthymic bipolar patients with and without subsyndromal symptoms等离子体浓度的可溶性细胞因子受体euthymic双相患者和没有亚综合征症状.pdfVIP

Cetin et al. BMC Psychiatry 2012, 12:158 /1471-244X/12/158 RESEARCH ARTICLE Open Access Plasma concentrations of soluble cytokine receptors in euthymic bipolar patients with and without subsyndromal symptoms 1† 2*† 3 3 3 4 Turan Cetin , Sinan Guloksuz , Esin Aktas Cetin , Sema Bilgic Gazioglu , Gunnur Deniz , E Timucin Oral and Jim van Os2,5 Abstract Background: Current evidence suggests that high concentrations of pro-inflammatory markers are associated with bipolar disorder characterized by severe impairment during inter-episodic periods, reduced treatment response and persistent subsyndromal symptoms. We tested whether persistent subsyndromal symptoms in euthymic bipolar patients were associated with markers of an ongoing chronic pro-inflammatory process. Methods: Forty-five euthymic bipolar patients (22 with subsyndromal symptoms (BD+) and 23 without subsyndromal symptoms (BD-) and 23 well controls (WC) were recruited for assessment of soluble tumor necrosis factor receptor-1 (sTNF-R1), soluble interleukin-6 receptor (sIL-6R) and soluble interleukin-2 receptor (sIL-2R) concentrations. Soluble cytokine receptor concentrations were assessed using enzyme-linked immunosorbent assay. Results: In comparison to WC, sTNF-R1 concentration was higher in both BD- and BD+ (age and sex adjusted standardized β, respectively: β = 0.34, p = 0.012 and β = 0.41, p = 0.003). Similarly, compared to WC, sIL-6R concentration was higher in both BD- and BD+ (age and sex adjusted standardized β, respectively: β = 0.44, p = 0.001 and β = 0.37, p = 0.008). There was no difference between BD- and BD+ in the concentration of either sTNF-R1 or sIL-6R; plasma concentration of sIL-2R was not analyzed as 75% percent of t