原创力文档plasma cytokine profiles in systemic sclerosis associations with autoantibody subsets and clinical manifestations血浆细胞因子在系统性硬化协会自身抗体子集和临床表现.pdfVIP
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plasma cytokine profiles in systemic sclerosis associations with autoantibody subsets and clinical manifestations血浆细胞因子在系统性硬化协会自身抗体子集和临床表现
Available online /content/11/5/R147
Vol 11 No 5 Open Access
Research article
Plasma cytokine profiles in systemic sclerosis: associations with
autoantibody subsets and clinical manifestations
Pravitt Gourh, Frank C Arnett, Shervin Assassi, Filemon K Tan, Mei Huang, Laura Diekman,
Maureen D Mayes, John D Reveille and Sandeep K Agarwal
Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, University of Texas Health Science Center at Houston, 6431
Fannin M.S.B. 5.278, Houston, TX 77030, USA
Corresponding author: Sandeep K Agarwal, Sandeep.K.Agarwal@
Received: 8 Jun 2009 Revisions requested: 7 Jul 2009 Revisions received: 19 Aug 2009 Accepted: 2 Oct 2009 Published: 2 Oct 2009
Arthritis Research Therapy 2009, 11:R147 (doi:10.1186/ar2821)
This article is online at: /content/11/5/R147
© 2009 Gourh et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Introduction Systemic sclerosis (SSc) (scleroderma) is a (P = 0.01) levels increased with advancing age. After adjusting
complex autoimmune disease that clinically manifests as for age and gender, SSc patients had higher circulating levels of
progressive fibrosis of the skin and internal organs. Anti- TNFα (P 0.0001), IL-6 (P 0.0001), and IFNγ (P = 0.05) and
centromere antibodies (ACAs), anti-topoisomerase antibodies lower IL-17 (P = 0.0005) and IL-23 (P = 0.014). Additional
(ATAs), and anti-RNA polymerase III ant
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