原创力文档plasma brain-derived neurotrophic factor levels, learning capacity and cognition in patients with first episode psychosis血浆脑源性神经营养因子水平、学习能力和认知首发精神病患者.pdfVIP
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plasma brain-derived neurotrophic factor levels, learning capacity and cognition in patients with first episode psychosis血浆脑源性神经营养因子水平、学习能力和认知首发精神病患者
Ruiz de Azua et al. BMC Psychiatry 2013, 13:27
/1471-244X/13/27
RESEARCH ARTICLE Open Access
Plasma brain-derived neurotrophic factor levels,
learning capacity and cognition in patients with
first episode psychosis
1 2 2,3 1 2 1
Sonia Ruiz de Azua , Carlos Matute , Laura Stertz , Fernando Mosquera , Aitor Palomino , Iris de la Rosa ,
1 1 3 1*
Sara Barbeito , Patricia Vega , Flávio Kapczinski and Ana González-Pinto
Abstract
Background: Cognitive impairments are seen in first psychotic episode (FEP) patients. The neurobiological
underpinnings that might underlie these changes remain unknown. The aim of this study is to investigate whether
Brain Derived Neurotrophic Factor (BDNF) levels are associated with cognitive impairment in FEP patients compared
with healthy controls.
Methods: 45 FEP patients and 45 healthy controls matched by age, gender and educational level were selected
from the Basque Country area of Spain. Plasma BDNF levels were assessed in healthy controls and in patients. A
battery of cognitive tests was applied to both groups, with the patients being assessed at 6 months after the acute
episode and only in those with a clinical response to treatment.
Results: Plasma BDNF levels were altered in patients compared with the control group. In FEP patients, we
observed a positive association between BDNF levels at six months and five cognitive domains (learning ability,
immediate and delayed memory, abstract thinking and processing speed) which persisted after controlling for
medications prescribed, drug use, intelligence quotient (IQ) and negative symptoms. In the healthy control grou
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